Cognitive decline in early Parkinson's disease
Identifieur interne : 000B36 ( Main/Exploration ); précédent : 000B35; suivant : 000B37Cognitive decline in early Parkinson's disease
Auteurs : Nagaendran Kandiah [Singapour] ; Kaavya Narasimhalu [Singapour] ; Puay-Ngoh Lau [Singapour] ; Soo-Hoon Seah [Singapour] ; Wing Lok Au [Singapour] ; Louis C. S. Tan [Singapour]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-03-15.
English descriptors
Abstract
Data on the prevalence and severity of cognitive impairment among patients with newly diagnosed idiopathic Parkinson's disease (PD) is limited. Using a prospectively collected clinical database, we studied the longitudinal trend of mini‐mental state examination (MMSE) change and baseline factors predictive for MMSE decline. One hundred six patients with mean age of 61.2 years and mean baseline MMSE of 27.8 ± 2.3 were studied. MMSE increased by 0.4 points/year among patients without cognitive decline (n = 73) and decreased by 2.39 points/year among patients with cognitive decline (n = 33). Univariate analysis demonstrated education, age of diagnosis, depression, and diabetes mellitus to be associated with cognitive decline. Motor scores and hallucination were not associated with cognitive decline. Multivariate analysis demonstrated higher level of education to be protective (HR = 0.91, 95% CI 0.82–0.99, P = 0.047) and depression having borderline significance in predicting cognitive decline (HR = 2.00, 95% CI 0.97–4.15, P = 0.061). We found that 31% of newly diagnosed idiopathic PD patients have measurable cognitive decline at an early stage of disease. Higher education is protective while depression may be predictive of cognitive decline. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22384
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15">2009-03-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="605">605</biblScope><biblScope unit="page" to="608">608</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">706EFE73D2FC65E7C452DFDD617D352F5C7F8A62</idno><idno type="DOI">10.1002/mds.22384</idno><idno type="ArticleID">MDS22384</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>cognition</term><term>depression</term><term>education</term><term>mini‐mental state examination</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Data on the prevalence and severity of cognitive impairment among patients with newly diagnosed idiopathic Parkinson's disease (PD) is limited. Using a prospectively collected clinical database, we studied the longitudinal trend of mini‐mental state examination (MMSE) change and baseline factors predictive for MMSE decline. One hundred six patients with mean age of 61.2 years and mean baseline MMSE of 27.8 ± 2.3 were studied. MMSE increased by 0.4 points/year among patients without cognitive decline (n = 73) and decreased by 2.39 points/year among patients with cognitive decline (n = 33). Univariate analysis demonstrated education, age of diagnosis, depression, and diabetes mellitus to be associated with cognitive decline. Motor scores and hallucination were not associated with cognitive decline. Multivariate analysis demonstrated higher level of education to be protective (HR = 0.91, 95% CI 0.82–0.99, P = 0.047) and depression having borderline significance in predicting cognitive decline (HR = 2.00, 95% CI 0.97–4.15, P = 0.061). We found that 31% of newly diagnosed idiopathic PD patients have measurable cognitive decline at an early stage of disease. Higher education is protective while depression may be predictive of cognitive decline. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Singapour</li></country><orgName><li>Université nationale de Singapour</li></orgName></list><tree><country name="Singapour"><noRegion><name sortKey="Kandiah, Nagaendran" sort="Kandiah, Nagaendran" uniqKey="Kandiah N" first="Nagaendran" last="Kandiah">Nagaendran Kandiah</name></noRegion><name sortKey="Au, Wing Lok" sort="Au, Wing Lok" uniqKey="Au W" first="Wing Lok" last="Au">Wing Lok Au</name><name sortKey="Au, Wing Lok" sort="Au, Wing Lok" uniqKey="Au W" first="Wing Lok" last="Au">Wing Lok Au</name><name sortKey="Lau, Puay Goh" sort="Lau, Puay Goh" uniqKey="Lau P" first="Puay-Ngoh" last="Lau">Puay-Ngoh Lau</name><name sortKey="Lau, Puay Goh" sort="Lau, Puay Goh" uniqKey="Lau P" first="Puay-Ngoh" last="Lau">Puay-Ngoh Lau</name><name sortKey="Narasimhalu, Kaavya" sort="Narasimhalu, Kaavya" uniqKey="Narasimhalu K" first="Kaavya" last="Narasimhalu">Kaavya Narasimhalu</name><name sortKey="Seah, Soo Oon" sort="Seah, Soo Oon" uniqKey="Seah S" first="Soo-Hoon" last="Seah">Soo-Hoon Seah</name><name sortKey="Seah, Soo Oon" sort="Seah, Soo Oon" uniqKey="Seah S" first="Soo-Hoon" last="Seah">Soo-Hoon Seah</name><name sortKey="Tan, Louis C S" sort="Tan, Louis C S" uniqKey="Tan L" first="Louis C. S." last="Tan">Louis C. S. Tan</name><name sortKey="Tan, Louis C S" sort="Tan, Louis C S" uniqKey="Tan L" first="Louis C. S." last="Tan">Louis C. S. Tan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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